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OHANA WELLNESS Hormone Balance

By Dr. Carolyn Candido

Hormone Balance is an ideal combination of DIM (diindolylmethane) and TrueBroc® (glucoraphanin)
that helps protect estrogen-sensitive tissues by promoting healthy estrogen metabolism and supporting detoxification and neutralization of harmful estrogen metabolites and xenoestrogens. *

• Supports Healthy Estrogen Metabolism*
• Supports a Healthy Ratio of 2-OH:16alpha-OH*
• Supports Detoxification of Estrogen Metabolites/Intermediates*
• Supports Cellular Health in Estrogen-Sensitive Tissues*
• Helps Protect Against Damaging Reactive Oxygen Species, DNADamaging
Electrophiles, and Cytokines
• Supports Antioxidant Activity with SGS*

Directions

Take one to two capsules daily, or as directed by your healthcare practitioner.
Consult your healthcare practitioner prior to use. Individuals taking medication or receiving cancer treatment should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain

Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives. 


Hormone Balance

Estrogen Metabolism and Detoxification Support Formula

Hormone Balance uses a dual-action approach to supporting healthy estrogen-sensitive tissues. First, it provides diindolylmethane (DIM) to promote healthy estrogen metabolism and create a better balance of estrogen metabolites (2-OH, 4-OH, 16alpha-OH) through phase I cytochrome P450 enzyme induction and promotion of 2-hydroxylation. Second, the action of DIM is complemented by providing sulforaphane glucosinolate (SGS), which protects tissues from unrestrained oxidative stress and uniquely supports phase II detoxification of harmful estrogen metabolites (e.g., estrogen quinones) and xenoestrogens. These actions may be important for the health of estrogensensitive
tissues, such as those of the breast, uterus, cervix, and prostate.*

DIM (diindolylmethane) DIM is an advanced metabolite of indole-3-carbinol (I3C), the indole found in cruciferous vegetables. Supplementation with DIM is preferred over I3C due to I3C’s undesirable breakdown products, including the dioxin-like molecule indolo[3,2-b] carbazole (ICZ).[1] It has been established that DIM supplementation increases 2-hydroxylation of estrogen. This science has been validated in animal and human studies wherein supplementation with DIM was shown to increase the ratio of the protective, “good” 2-hydroxyestrone (2-OH) to 16alpha hydroxyestrone (16alpha-OH).[2,3] In a study of postmenopausal women, DIM-treated subjects, relative to placebo, showed an increase of 47% in 2-OH/16alpha-OH.[4] Studies further reveal that DIM may play a critical role in supporting normal cellular proliferation in estrogen-sensitive tissues.*[3,5,6]

Sulforaphane Glucosinolate (SGS) Sulforaphane is the aglycone breakdown product of glucoraphanin, a glucosinolate also known as SGS. The SGS broccoli seed extract used in Hormone Balance is a super vegetable that delivers extended antioxidant support and boasts a very high level of glucoraphanin (13%). Research suggests that when SGS is broken down to sulforaphane (its active form), it safely and effectively upregulates the Nrf2 system, activates the antioxidant response element (ARE), enhances the production of important antioxidants, and activates vital phase II detoxification enzymes.[7] These mechanisms provide protection from toxins, xenobiotics (e.g., xenoestrogens), and reactive intermediates formed after phase I detoxification. *

Neutralizing Reactive Estrogen Quinones with SGS According to Bolton et al, the oxidation of catechol estrogens (2-OH and 4-OH) via cytochrome P450 enzymes generates reactive electrophilic estrogen quinones and reactive oxygen species (ROS) through redox cycling.[8] Formation of quinones is largely minimized via phase II methylation, which produces methoxyestrogens. However, if methylation is suboptimal, estrogen quinones, which can cause DNA damage in estrogen-sensitive tissues, must be neutralized via other phase II enzymes such as quinone reductase. According to researchers, estrogen quinones are now recognized as a significant mechanism of estrogen-mediated cell damage.[8,9] A promising strategy to address their deleterious effects involves the use of agents to favorably shift the balance between phase I and phase II enzymes.[9] In fact, phase II enzymes such as quinone reductase, heme oxygenase-1 (HO-1), and glutathione S-transferase (GST) have been suggested as targets for reducing these highly reactive estrogen quinones.*

Sulforaphane has been identified as an agent that possesses the ability to potently induce phase II detoxification enzymes—including quinone reductase, HO-1, GST, and glutathione reductase—as well as to inhibit phase I enzymes involved in activation.[10-12] In the case of estrogen quinones, quinone reductase protects cells from oxidative damage by two-electron reduction, thus suppressing oxidative cycling and reactive oxygen species generation.[10] Sulforaphane consumption is associated with supporting cell-line health in humans, and animal research shows that sulforaphane metabolites can be found in target tissues, along with significant induction of quinone reductase and
HO-1.[10] This research has exciting implications for supporting the health of tissues as it relates to reactive estrogen quinones formed after phase I activation of catechol estrogens (2-OH, 4-OH).*[10

OHANA WELLNESS Testosterone Support

By Dr. Carolyn Candido

Testosterone Support features two safe, clinically-tested, standardized, and patented ingredients
designed to support vitality and general physical and mental well-being in men and women. Numerous studies have demonstrated that PrimaVie® shilajit and LJ100® Eurycoma longifolia support healthy androgen biosynthesis, which includes modulating the influence of sex hormone-binding globulin.†

• Supports Healthy Testosterone Levels†
• Supports Healthy Libido and Performance†
• Supports Overall Vitality†
• Optimizes Physical Strength and Endurance†
• Supports Cognition†

Directions
Take two capsules in the morning, or as directed by your healthcare professional.
Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Testosterone Support

Supports Vitality, Virility, and Vigor*

Five percent of males aged 40-50 years and as many as 70% of males over 70 years are confronted with “hypogonadism.” Low testosterone levels have been associated with a decline in libido, erectile dysfunction, lack of energy, less physical strength and endurance, loss of height, decreased enjoyment in life, low mood, feeling grumpy, falling asleep after dinner, and decreased work performance. [1,2] Some studies suggest that low testosterone may also contribute to cognitive decline.†[3,4]
Although sometimes thought of as a male hormone, a review study of the clinical significance of testosterone has shown its positive association with sexual function and a healthy libido in women.†[5]
Most circulating testosterone is bound to sex hormone-binding globulin (SHBG). Only the lesser amount of testosterone not bound to SHBG is considered bioavailable.[6] Testosterone Support features a blend of ingredients designed to support healthy androgen biosynthesis, which includes modulating the influence of SHBG.† 

Shilajit is a naturally occurring, mineral-rich phytocomplex with many bioactive components, including fulvic acids. It comprises rock humus, rock minerals, and organic substances that have been compressed by layers of rock mixed with marine organisms and microbial metabolites.[7] Shilajit has a rich history of use in Indian ayurvedic and siddha medicine as a health and wellness optimizer. It is known as a rasayana because of its rejuvenating qualities, which include heightening physical performance and relieving fatigue.†[8]
According to an article in the American Journal of Clinical Nutrition, weightlifters use shilajit to promote better strength, recovery, and muscular hypertrophy and also to combat physical stress, but human data on these uses are lacking.†[9]
Animal and human studies have documented the safety of shilajit. The oral median lethal dose (LD50) is > 200 grams, and chronic use at doses of 0.2–1.0 g/kg body weight appear to be safe.†[7]
Upwards of 50 studies on shilajit suggest that it has a positive effect on testosterone levels and adaptogenic, antioxidant, cytokinebalancing, immunomodulatory, and antidyslipidemic activities.[10] Fulvic acid, the main bioactive component in shilajit, blocks tau proteins self-aggregation suggesting it may have a role in supporting cognition.†[11]

PrimaVie® shilajit at a dose of 250 mg/capsule consumed twice daily after major meals for 90 days was evaluated in 75 healthy male volunteers aged 45-55 for its testosterone secretion efficacy and its stimulation effects. This double-blind placebo-controlled study revealed that PrimaVie shilajit, when compared to placebo, significantly (P < 0.05) increased total testosterone, free testosterone, and dehydroepiandrosterone (DHEA). The levels of testosterone synthesis-supportive gonadotropic hormones were well-maintained.†[7]
Another study further demonstrated the safety and also the spermatogenic nature of shilajit. Infertile males (n = 35) took 100 mg of PrimaVie shilajit twice daily after major meals for 90 days. At completion, 28 of the subjects had significant (P < 0.001) improvement compared to baseline values of factors related to fertility. Furthermore, at the study’s completion, the semen’s content of malondialdehyde (MDA), a marker for oxidative stress, was reduced. High-performance liquid chromatography (HPLC) revealed that the semen had constituents of PrimaVie shilajit. Compared to baseline, serum levels of testosterone rose 23.5% (P < 0.001) and follicle-stimulating hormone (FSH) rose 9.4% (P < 0.05). Liver and kidney profiles were unchanged.†[12] 

In addition, the safe use of PrimaVie shilajit in either gender was demonstrated in an experimental study on skeletal muscle adaptation in human subjects (n = 16), ages 21-70 years. Participants were given 250 mg of PrimaVie with no adverse effects during the 12-week study period. †[13] 

Eurycoma longifolia root (Malaysian ginseng) is considered a tonic and an adaptogen for supporting healthy libido, energy, sports performance, and weight management by promoting healthy testosterone levels and freeing testosterone from SHBG. Eurypeptides activate the CYP-17 enzyme, which plays a key role in production of DHEA, progesterone, testosterone, and pheromone via the
metabolism of pregnenolone. A systemic review and meta-analysis of randomized controlled studies (n = 139) concluded that the herbal extract “may have clinical effect on erectile function. However, more efficacy trials are warranted to further support current evidence.”†[14] 

LJ100® Eurycoma longifolia is a root extract whose safety and efficacy is backed by animal and at least 12 human clinical studies. Compound isolation, a patented water-extraction process, and technologically advanced manufacturing methods ensure the purity of this ingredient and allow for the capture of the potent, biologically active eurypeptides.†

A randomized, placebo-controlled, two-month study (n = 20) focused on the outcomes of LJ100 on various parameters in male volunteers aged 38-58 who had varied health conditions and consumed either a placebo or 200, 400, or 600 mg of LJ100. The herb-consuming volunteers showed improvement in sexual desire and performance. Also, testosterone and DHEA levels were high-normal when compared to baseline; HDL cholesterol improved; those who had type-2 diabetes showed improvement in blood glucose levels; and insulin-like growth factors (IGF-1) were high-normal (lower levels of IGF-1 are correlated with higher body fat). Compared to those on placebo, the majority of the volunteers on LJ100 had high-normal levels of thyroxine suggesting higher metabolism. Blood and lipid panels and liver and renal function profiles, electrolytes, and various tumor markers including prostate-specific antigen (PSA) were within normal range. †[15] 

The benefits of LJ100 are not limited to males or particular age groups. Two studies, one in middle-aged and one in senior males and females, demonstrated the herb’s promotion of healthy fitness, vitality, and vigor concomitant with an increase in free testosterone and a decline in SHBG.†[16,17] In summary, it appears that the combination of these two herbs supports healthy testosterone levels in men and women which, in turn, supports vitality, virility, and vigor. †

OHANA WELLNESS Thyroid Activator

By Dr. Carolyn Candido

Thyroid Activator features targeted nutrients and herbs that support healthy thyroid hormone biosynthesis.
This combination may facilitate the expression of thyroid hormone genes. The addition of ashwagandha and guggul extract may aid in the conversion of thyroxine to triiodothyronine (T4 to T3) and may assist in maintaining healthy blood lipid levels already within the normal range.*

• Supports Healthy Thyroid Function*
• Supports the Body’s Conversion of T4 to the More Active Hormone T3*

Directions
Take two capsules daily, or as directed by your healthcare professional.
Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Cautions  
Do not take if you are pregnant or lactating. Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who might become pregnant should not exceed 1,500 mcg RAE of preformed vitamin A (retinyl palmitate) per day.

Thyroid Activator

Thyroid Support Formula*

Iodine The thyroid gland produces two main iodine-containing hormones: thyroxine (T4) and triiodothyronine (T3). These hormones circulate in the bloodstream and work on every living tissue and cell to regulate metabolism and growth. Of the body’s iodine pool (about 15 mgs in adults), 80% is contained in the thyroid gland. Iodine is primarily used as a substrate for the manufacture of T4 and T3, and healthy iodine status is imperative for normal thyroid function and thyroid hormone biosynthesis. [1,2] Because excessive iodine intake, like inadequate iodine intake, can negatively impact thyroid function, total supplementary and dietary iodine should be considered.[2] Thyroid Activator provides 75 mcg of iodine from Atlantic kelp in each serving. * 

Selenium While the role of iodine has long been known, the mechanisms by which selenium exerts its beneficial effects on the thyroid gland have been elucidated more recently. According to Arthur et al, “Selenium is an essential component of many selenoproteins that regulate thyroid hormone synthesis, preserve thyroid integrity in conditions of marked oxidative stress, and control hormone metabolism in nonthyroidal tissues where the prohormone T4 is converted to biologically active T3 or its inactive isomer rT3.”[2] The interactive and complementary relationship between iodine and selenium has become an area of interest and research. For instance, in an animal study, it was observed that a high iodine intake in the presence of selenium deficiency may permit thyroid tissue damage as a result of low thyroidal glutathione peroxidase activity. It was further noted that even a low selenium intake helped normalize circulating T4 concentration in the presence of iodine deficiency.[3] Evaluation of emerging data supports “selenostasis” as an important aspect of thyroid health.* [4] 

Zinc and Vitamins A and D Research suggests that inadequate intakes of zinc and vitamins A and D may impact thyroid hormone metabolism, circulating thyroid hormone concentrations, the thyroid’s response to iodine prophylaxis, and antithyroid antibody levels.[2,5-7] Researchers further propose that vitamins A and D could increase the transcriptional activity of the thyroid hormone receptor-regulated genes.[8] Expression of these genes affects growth, differentiation, development, and metabolic homeostasis. More studies into the roles of zinc and vitamins A and D will help to gain a better understanding of how these nutrients interact with thyroid hormones, iodine, selenium, and each other to influence thyroid health. * 

Retinyl palmitate is used in this formula rather than beta-carotene because certain individuals may lack the ability to effectively convert betacarotene or other carotenoids into vitamin A.[9] It is also important to note that vitamin D facilitates intestinal calcium absorption and therefore helps maintain the ratio of calcium to phosphorous, which can be affected by low thyroid function and certain thyroid therapies. *[10,11]

Vitamin E and Rosemary “Oxidative stress” denotes an imbalance between the production of oxidants and their elimination by antioxidative systems. Studies support the concept of reducing oxidative stress in order to protect thyroid cell health and maintain normal thyroid cell growth and lifecycle.[12] Furthermore, because active oxygen radicals can inhibit the activity of an enzyme involved in the conversion of T4 to T3, reducing oxidative stress may have a two-fold application in thyroid health.[13] Antioxidative components in Thyroid Activator, such as vitamin E and rosemary, may help protect thyroid cells/tissue and also support the enzymatic conversion of T4 to T3 by scavenging damaging free radicals.*[13,14] 

Guggulsterones and Ashwagandha Researchers have demonstrated the positive influence guggul extract can have on thyroid function and blood lipid metabolism. In one study, the gum resin of Commiphora mukul (guggulu) reversed induced decreases in thyroid hormone and 5’-deiodinase activity in an animal model of low thyroid function.[15] Ashwagandha (Withania somnifera) is an Ayurvedic herbal tonic or adaptogen that has been used for thousands of years. Animal research suggests that ashwagandha is capable of stimulating thyroid function in mice.[16]

All Ohana MedSpas LLC Formulas Meet or Exceed cGMP Quality Standards

Distributed By: Ohana MedSpas LLC
500 Ala Moana Blvd. Suite 5i
Honolulu, HI 96813

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